KPV Peptide

KPV (Lys-Pro-Val) is a tripeptide corresponding to the C-terminal amino acids 11-13 of alpha-melanocyte-stimulating hormone (alpha-MSH). Despite being only three amino acids in length, published research suggests KPV retains significant biological activity derived from the parent hormone. Alpha-MSH is a 13-amino acid peptide produced from proopiomelanocortin (POMC) processing. Research identified that the C-terminal KPV sequence carries much of the anti-inflammatory signaling activity of the full-length peptide, independent of melanocortin receptor activation. For laboratory research use only.

NF-kB Pathway Modulation Published research indicates KPV may directly inhibit NF-kB activation. Studies suggest the tripeptide can enter cells and interact with components of the NF-kB signaling cascade, potentially inhibiting IkB kinase (IKK) activity and preventing nuclear translocation of NF-kB. This mechanism is distinct from melanocortin receptor-mediated signaling. Transepithelial Transport Research has demonstrated that KPV can cross epithelial barriers via the peptide transporter PepT1 (SLC15A1). This oligopeptide transporter is expressed in intestinal epithelium and actively transports di- and tripeptides. The ability to cross epithelial barriers without degradation is notable for such a small peptide. Inflammasome Modulation Studies have investigated KPV interaction with inflammasome pathways, particularly NLRP3. Research suggests KPV may reduce inflammasome activation and downstream IL-1beta and IL-18 processing, providing an additional anti-inflammatory mechanism independent of NF-kB modulation.