What Vesugen Is
Vesugen is a synthetic tripeptide, Lys-Glu-Asp (KED), C15H26N4O8, 390.39 g/mol. Within the peptide bioregulator family it is classified as vascular-associated.
KED is the structural hub of this family. Three other catalog compounds are the same tripeptide with one residue added: Prostamax is KED + proline, Livagen is KED + alanine, and Pancragen is KED + tryptophan. That makes Vesugen the natural reference point for any question about how a single added residue changes behaviour.
Research use only. Supplied for laboratory research. Not for human or veterinary use. No marketing authorisation exists and no therapeutic claim is made.
What the Published Literature Contains
No PubMed-indexed study names Vesugen in its title. There is no compound-specific work establishing a biological effect, a mechanism tied to this sequence, a safety profile, or an amount for any species.
The class-level literature describes short peptides generally: the systematic review of peptide regulation of gene expression (Khavinson et al., Molecules 2021, PMID 34834147), and work on a vascular peptide preparation and microvascular density in aged rat brain cortex (Sokolova et al., Bull Exp Biol Med 2016, PMID 27383168).
That second paper is the one most often cited as if it were a Vesugen study. It is not: it concerns a vascular peptide preparation within the same programme, not KED under this name. The distinction matters when the vascular association is being used as a premise.
The Contrast Worth Designing Around
Pancragen — KED plus a single tryptophan — has six papers naming it, including primate work. Vesugen has none. One residue separates the best-documented compound in this family from one with no compound-specific literature at all.
If the research question is whether the family's tissue assignments track sequence or are conventional labels, that pair is the cleanest available comparison.
Structure and Handling
- Sequence. Lys-Glu-Asp (KED), tripeptide.
- Formula. C15H26N4O8, 390.39 g/mol.
- Form. Lyophilised powder, ≥98% purity, third-party certificate of analysis per batch.
- Storage. Sealed vial at −20 °C, protected from light; reconstituted solution at 2–8 °C.
- Reconstitution. Bacteriostatic water down the vial wall, never onto the powder cake. Do not shake. See the reconstitution calculator.
Related Compounds
Do not confuse Vesugen with Vesilut: they are different molecules — Vesilut is the dipeptide Glu-Asp. For compounds with substantive published work see Vilon, Pancragen and Epithalon. Full family on the bioregulator overview.