Prostamax (Lys-Glu-Asp-Pro): Chromatin Effects in Human Lymphocytes

Prostamax has two published studies naming it, both in human lymphocytes and both aimed at chromatin rather than prostate tissue. What they report, and what the prostate label rests on.

· · 2 min read
prostamax bioregulator khavinson Lys-Glu-Asp-Pro KEDP chromatin heterochromatin lymphocytes

Key Research Findings

  • Prostamax is the tetrapeptide Lys-Glu-Asp-Pro (KEDP), C20H33N5O9, 487.51 g/mol — KED plus a proline.
  • Two published studies name it, both in human lymphocytes.
  • The primary one tests the family chromatin hypothesis directly: heterochromatin in human lymphocytes in situ (PMID 15612551).
  • Neither study concerns prostate tissue — the prostate label is a family classification, untested for this sequence.
  • The second study is biophysical, with the peptide alongside metal ions rather than as a sole intervention.
  • No amount is established for any species.

What Prostamax Is

Prostamax is a synthetic tetrapeptide, Lys-Glu-Asp-Pro (KEDP), C20H33N5O9, 487.51 g/mol. Within the bioregulator family it is the prostate-associated member, and it is Vesugen's KED tripeptide extended by a proline.

Two published studies name it. Both are worth reading for what they are not: neither is a prostate study.

Research use only. Supplied for laboratory research. Not for human or veterinary use. No marketing authorisation exists and no therapeutic claim is made.

What the Two Studies Report

Heterochromatin in human lymphocytes

The primary paper examines the influence of the peptide bioregulator prostamax on heterochromatin of human lymphocytes in situ (Meskhi et al., Biofizika 2004, PMID 15612551).

This is a direct test of the family's central proposition — that short peptides act on chromatin — carried out in primary human cells rather than inferred from a downstream phenotype. It is the same experimental line as the Livagen chromatin work, and the two are best read together.

Microcalorimetry with metal ions

A second study used microcalorimetry on human blood lymphocyte cultures in the presence of copper, cadmium and prostamax (Kiladze et al., Georgian Med News 2009, PMID 19359734). The design is biophysical — it measures heat exchange in cell cultures — and the peptide appears alongside metal ions rather than as a sole intervention.

What the Prostate Label Rests On

Nothing in either paper concerns prostate tissue. The prostate association comes from the family's classification scheme, not from a published experiment on this sequence.

That does not make the label wrong; it makes it untested. If prostate activity is the research question, that gap belongs in the design rather than in the citation list.

Structure and Handling

  • Sequence. Lys-Glu-Asp-Pro (KEDP), tetrapeptide.
  • Formula. C20H33N5O9, 487.51 g/mol.
  • Form. Lyophilised powder, ≥98% purity, third-party certificate of analysis per batch.
  • Storage. Sealed vial at −20 °C, protected from light; reconstituted solution at 2–8 °C.
  • Reconstitution. Bacteriostatic water down the vial wall, never onto the powder cake. Do not shake. See the reconstitution calculator.

KEDP is KED plus proline. Vesilut (Glu-Asp) is a fragment contained within it. Pancragen (KED + Trp) has the family's largest literature. Full set on the bioregulator overview.

Frequently Asked Questions

What is Prostamax?

Prostamax is a synthetic tetrapeptide, Lys-Glu-Asp-Pro (KEDP), C20H33N5O9, 487.51 g/mol, classified within the Khavinson bioregulator family as prostate-associated. Structurally it is the KED tripeptide extended by a proline residue.

What does the research on Prostamax show?

Two studies name it. One examines its influence on heterochromatin of human lymphocytes in situ (PMID 15612551) — a direct test of the family chromatin hypothesis in primary human cells. The other is a microcalorimetric study of lymphocyte cultures with copper, cadmium and prostamax (PMID 19359734).

Is the prostate association supported by research?

Not directly. Neither published study concerns prostate tissue; both are lymphocyte studies. The prostate label comes from the family classification scheme rather than from an experiment on this sequence. That makes it untested rather than wrong.

Is there an established Prostamax dosage?

No. No controlled human programme exists, so no published figure is available for any population or context.

How does Prostamax relate to Vesugen and Vesilut?

Prostamax is KEDP — the KED tripeptide of Vesugen plus a proline. The Glu-Asp pair that constitutes Vesilut is contained within it. All three are distinct molecules.

References

  1. Meskhi T, Lezhava T, Khavinson VKh. The influence of the peptide bioregulator prostamax on heterochromatin of human lymphocytes in situ Biofizika (2004)
  2. Kiladze M, Monaselidze J, Gorgoshidze M, Khavinson VKh. Microcalorimetric study of human blood lymphocytes culture at presence of copper, cadmium and prostamax Georgian Medical News (2009)
Research Use Only: This content is intended for laboratory and scientific research purposes only. It is not intended for human use, medical advice, diagnosis, or treatment. All compounds discussed are for in vitro and preclinical research contexts.

Related Articles

Cardiogen (Ala-Glu-Asp-Arg): Myocardial Tissue Culture and a Sarcoma Model

Aug 6, 2026 · 2 min

Bronchogen (Ala-Glu-Asp-Leu): DNA Thermostability and a Sequence Discrepancy

Aug 6, 2026 · 2 min

Testagen (Lys-Glu-Asp-Gly): Its Only Published Study Is About Metal Corrosion

Aug 6, 2026 · 2 min