Vesilut / Vesilute (Glu-Asp): The Smallest Bioregulator, and a Fragment of a Larger One

Vesilut is the dipeptide Glu-Asp (ED) — a sequence contained within Prostamax, Vesugen, Livagen and Pancragen. Shared substructure is a hypothesis to test, not evidence to cite.

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vesilut vesilute bioregulator khavinson Glu-Asp ED dipeptide bladder evidence status

Key Research Findings

  • Vesilut (Vesilute, ED) is the dipeptide Glu-Asp, C9H14N2O7, 262.22 g/mol — PubChem CID 99716.
  • It is a distinct molecule from Vesugen (Lys-Glu-Asp), not the same compound under another name.
  • The Glu-Asp pair is contained within Prostamax, Vesugen, Livagen and Pancragen.
  • Shared substructure is a hypothesis to test, not evidence that activity is preserved.
  • No PubMed-indexed study names Vesilut or Vesilute.
  • No amount is established for any species.

What Vesilut Is

Vesilut — also written Vesilute, and abbreviated ED — is the dipeptide Glu-Asp, C9H14N2O7, 262.22 g/mol, catalogued as PubChem CID 99716 (L-alpha-glutamyl-L-aspartic acid).

At two residues it is among the smallest compounds in the bioregulator family, alongside Vilon (Lys-Glu) and Thymogen (Glu-Trp). It is associated with bladder tissue in the family's classification.

Research use only. Supplied for laboratory research. Not for human or veterinary use. No marketing authorisation exists and no therapeutic claim is made.

A Fragment of a Larger Sequence

The structurally interesting fact about ED is that it is contained within a longer family member: the Glu-Asp pair appears inside Prostamax (Lys-Glu-Asp-Pro), and likewise inside Vesugen (Lys-Glu-Asp), Livagen (Lys-Glu-Asp-Ala) and Pancragen (Lys-Glu-Asp-Trp).

This is worth stating carefully. Shared substructure is a reason to ask whether activity is preserved; it is not evidence that it is. A dipeptide fragment and the tetrapeptide containing it are different molecules with different size, charge distribution and conformational freedom. Any expectation that ED behaves like Prostamax is a hypothesis to test, not a finding to cite.

What the Published Literature Contains

No PubMed-indexed study names Vesilut or Vesilute in its title. No compound-specific work establishes an effect on bladder or prostate tissue, a mechanism tied to Glu-Asp, a safety profile, or an amount for any species.

The literature cited around this compound is class-level: peptide regulation of gene expression (PMID 34834147) and short peptides regulating gene expression (PMID 27909961). Neither tested ED.

What This Means for Research Design

ED is a good subject if the question is about minimal sequence length — what is the smallest fragment that retains any measurable activity within this family. It is a poor choice as a positive control or benchmark, because nothing about its own behaviour has been published.

Structure and Handling

  • Sequence. Glu-Asp (ED), dipeptide.
  • Formula. C9H14N2O7, 262.22 g/mol (PubChem CID 99716).
  • Also known as. alpha-glutamylaspartic acid, ED, Vesilute.
  • Form. Lyophilised powder, ≥98% purity, third-party certificate of analysis per batch.
  • Storage. Sealed vial at −20 °C, protected from light; reconstituted solution at 2–8 °C.
  • Reconstitution. Bacteriostatic water down the vial wall, never onto the powder cake. Do not shake. See the reconstitution calculator.

Vesugen (Lys-Glu-Asp) is a different molecule and should not be confused with this one. Prostamax contains the ED pair within a longer sequence. Full family on the bioregulator overview.

Frequently Asked Questions

What is Vesilut?

Vesilut — also written Vesilute, abbreviated ED — is the dipeptide Glu-Asp, C9H14N2O7, 262.22 g/mol, catalogued as PubChem CID 99716 (L-alpha-glutamyl-L-aspartic acid). It is among the smallest compounds in the Khavinson bioregulator family and is associated with bladder tissue in the family classification.

Is Vesilut the same as Vesugen?

No. They are distinct molecules. Vesilut is the dipeptide Glu-Asp (262.22 g/mol); Vesugen is the tripeptide Lys-Glu-Asp (390.39 g/mol). An earlier version of our material stated they were the same compound; that was incorrect and has been corrected.

Does Vesilut work like Prostamax because they share a sequence?

That is a hypothesis, not a finding. The Glu-Asp pair does appear inside Prostamax (Lys-Glu-Asp-Pro), but a dipeptide fragment and the tetrapeptide containing it are different molecules with different size, charge distribution and conformational freedom. Shared substructure is a reason to ask the question, not evidence of the answer.

Is there published research on Vesilut?

No PubMed-indexed study names Vesilut or Vesilute in its title. No compound-specific work establishes an effect on bladder or prostate tissue, or a mechanism tied to Glu-Asp.

What is the Vesilut dosage?

No amount is established for any species or context, because no published study on this compound reports one.

References

  1. Khavinson VK, Popovich IG, Linkova NS, Mironova ES, Ilina AR. Peptide regulation of gene expression: a systematic review Molecules (2021)
  2. Khavinson VK, Solov'ev AY, Zhilinskiĭ DV, Shataeva LK, Bashkirev NA. Short peptides regulate gene expression Bulletin of Experimental Biology and Medicine (2016)
Research Use Only: This content is intended for laboratory and scientific research purposes only. It is not intended for human use, medical advice, diagnosis, or treatment. All compounds discussed are for in vitro and preclinical research contexts.

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