≥98%HPLC Purity
COAIncluded
USAShipped
CJC-1295 DAC Peptide
Modified growth hormone releasing hormone analog with Drug Affinity Complex. A 30-amino acid peptide conjugated with maleimidopropionic acid-lysine.
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| SKU | ACR-CJC1295D |
|---|---|
| CAS Number | 863288-34-0 |
| Molecular Weight | 3367.97 g/mol |
| Sequence | 30-amino acid GHRH analog + DAC |
| Purity | ≥98% |
| Physical Form | Lyophilized Powder |
| Storage | Store at -20°C |
What is CJC-1295 DAC?
CJC-1295 DAC (Drug Affinity Complex) is a synthetic analog of growth hormone-releasing hormone (GHRH) with a DAC modification that extends its half-life to approximately 6-8 days. This prolonged duration enables sustained elevation of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels, making it a key compound in endocrine research.
The DAC modification binds to serum albumin via a reactive chemical group, significantly reducing renal clearance and enabling less frequent dosing protocols in research settings compared to CJC-1295 without DAC (Modified GRF 1-29).
Mechanism of Action
CJC-1295 DAC acts as a GHRH analog, binding to the GHRH receptor (GHRHR) on anterior pituitary somatotroph cells. This triggers a signaling cascade via the cAMP/PKA pathway, stimulating the synthesis and pulsatile release of growth hormone.
The DAC moiety consists of a maleimidopropionic acid (MPA) linker conjugated to lysine, which undergoes a Michael reaction with Cys34 on albumin. This albumin binding reduces proteolytic degradation and renal filtration, extending the peptide's functional half-life from ~30 minutes (without DAC) to approximately 6-8 days.
Research & Clinical Studies
CJC-1295 DAC and Growth Hormone Research
In preclinical and early clinical studies, CJC-1295 DAC demonstrated dose-dependent increases in GH secretion. A 2006 study by Teichman et al. found that a single subcutaneous injection of CJC-1295 resulted in sustained GH elevation for 6+ days, with IGF-1 levels remaining elevated for up to 14 days.
The study reported mean GH levels increased 2-10 fold above baseline, with peak IGF-1 increases of 1.5-3 fold depending on dosage. The compound maintained the natural pulsatile pattern of GH secretion rather than producing a continuous, non-physiological elevation.
[1] Teichman SL et al. Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295. J Clin Endocrinol Metab. 2006;91(3):799-805. PubMed ↗
Chemical & Physical Properties
CJC-1295 DAC is a 30-amino acid peptide with a molecular weight of approximately 3647.28 g/mol. The peptide is supplied as a white to off-white lyophilized powder with ≥98% purity as determined by HPLC analysis. The CAS number is 863288-34-0.
Handling & Reconstitution
Reconstitute CJC-1295 DAC with bacteriostatic water. Add solvent slowly along the vial wall — do not shake or agitate vigorously. Allow 5-10 minutes for complete dissolution. The reconstituted solution should be clear and colorless.
Storage & Stability
Store lyophilized CJC-1295 DAC at -20°C for long-term stability (up to 24 months). After reconstitution, store at 2-8°C and use within 21 days. Protect from light and repeated freeze-thaw cycles.
Frequently Asked Questions
What is the difference between CJC-1295 DAC and CJC-1295 without DAC?
CJC-1295 DAC includes a Drug Affinity Complex that binds to serum albumin, extending its half-life to 6-8 days versus ~30 minutes for CJC-1295 without DAC (Modified GRF 1-29). This means DAC version provides sustained GH elevation while the non-DAC version produces shorter, more physiological GH pulses.
What is the purity of your CJC-1295 DAC?
Our CJC-1295 DAC is manufactured to ≥98% purity, verified through third-party HPLC and mass spectrometry analysis. A Certificate of Analysis (COA) is included with every order.
How should CJC-1295 DAC be stored?
Lyophilized: -20°C for up to 24 months. Reconstituted: 2-8°C for up to 21 days. Protect from light and avoid freeze-thaw cycles.
What sizes are available?
CJC-1295 DAC is available in 2mg and 5mg lyophilized vials, suitable for various research protocol durations.
For laboratory and research use only. Not intended for human or animal consumption. All product information is derived from published preclinical research and does not constitute medical advice or claims.