≥98%HPLC Purity
COAIncluded
USAShipped
Triptorelin Peptide
Synthetic decapeptide GnRH agonist (gonadotropin-releasing hormone analog) for reproductive endocrinology research. Studied for LH/FSH modulation and hormonal signaling pathways.
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Quick Facts
| SKU | TRIP-001 |
|---|---|
| CAS Number | 57773-63-4 |
| Molecular Formula | C₆₄H₈₂N₁₈O₁₃ |
| Molecular Weight | 1311.45 g/mol |
| Sequence | pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH₂ |
| Purity | ≥98% |
| Physical Form | Lyophilized Powder |
| Storage | Store at -20°C |
What is Triptorelin?
Triptorelin is a synthetic decapeptide analog of gonadotropin-releasing hormone (GnRH/LHRH). It is approximately 100x more potent than native GnRH due to the substitution of D-Trp at position 6 and deletion of Gly-NH2 at position 10, conferring resistance to enzymatic degradation. Initially, triptorelin stimulates LH/FSH release (flare effect), followed by sustained receptor desensitization and downregulation.
Mechanism of Action
Triptorelin binds GnRH receptors on pituitary gonadotrophs. Acute administration causes an initial burst of LH and FSH (flare effect, days 1-7). Continuous exposure desensitizes GnRH receptors via receptor internalization and downregulation, reducing LH/FSH to castrate levels by day 14-21. This biphasic response is central to its research utility.
Frequently Asked Questions
What is the triptorelin flare effect?
The initial 1-7 day period where triptorelin causes paradoxical LH/FSH increase before receptor desensitization occurs. After 2-3 weeks, hormone levels drop to suppressed levels as pituitary GnRH receptors are downregulated.
For laboratory and research use only. Not intended for human or animal consumption. All product information is derived from published preclinical research and does not constitute medical advice or claims.