≥98%HPLC Purity
COAIncluded
USAShipped
Testagen Peptide
Khavinson bioregulatory tetrapeptide (Lys-Glu-Asp-Gly) for testicular function and testosterone regulation research. Normalizes Leydig cell gene expression and steroidogenic enzyme activity in aging models.
Coming Soon
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Quick Facts
| SKU | AC-TESTAGEN |
|---|---|
| Sequence | Lys-Glu-Asp-Gly (KEDG) |
| Purity | ≥98% |
| Physical Form | Lyophilized Powder |
| Storage | Store at -20°C |
What is Testagen?
Testagen is a synthetic bioregulatory tetrapeptide with the sequence Lys-Glu-Asp-Gly (KEDG), developed by Professor Vladimir Khavinson as part of the bioregulatory peptide family. It is derived from testicular tissue extracts and specifically targets Leydig cell gene expression to normalize testosterone synthesis in aging models.
In the Khavinson bioregulator classification, Testagen is the tissue-specific peptide for male reproductive function, analogous to how Epithalon targets the pineal gland and Thymalin targets the thymus. Research shows it upregulates steroidogenic enzymes (StAR protein, CYP11A1, CYP17A1) at the transcriptional level rather than directly stimulating hormone release.
Mechanism of Action
Gene Expression Regulation: Testagen acts at the epigenetic level in Leydig cells, modulating chromatin accessibility of steroidogenic gene promoters. It upregulates: StAR protein (rate-limiting cholesterol transport), CYP11A1 (cholesterol side-chain cleavage), and CYP17A1 (17α-hydroxylase/17,20-lyase) — the three key enzymes in the testosterone biosynthetic pathway.
Age-Related Normalization: Leydig cell testosterone production declines ~1-2% per year after age 30 due to progressive epigenetic silencing of steroidogenic genes. Testagen research shows partial reversal of this age-related gene silencing, restoring enzyme expression to younger levels without causing supraphysiological hormone production.
Chemical Properties
| Sequence | Lys-Glu-Asp-Gly (KEDG) |
|---|---|
| Type | Khavinson bioregulatory tetrapeptide |
| Amino Acids | 4 |
| Target Tissue | Leydig cells (testicular interstitium) |
| Mechanism | Epigenetic upregulation of steroidogenic enzymes |
| Purity | ≥98% |
| Availability | Coming Soon |
Frequently Asked Questions
How does Testagen differ from testosterone replacement?
Testagen normalizes endogenous testosterone production by upregulating steroidogenic enzyme gene expression in Leydig cells. It does not introduce exogenous testosterone — there is no negative feedback suppression, no testicular atrophy, and production normalizes rather than becoming supraphysiological.
Is Testagen related to Epithalon?
Both are Khavinson bioregulatory tetrapeptides with the same conceptual approach: short peptides that normalize tissue-specific gene expression. Epithalon targets pineal gland (AEDG), Testagen targets Leydig cells (KEDG). Different sequences, different tissues, same bioregulatory principle.
For laboratory and research use only. Not intended for human or animal consumption. All product information is derived from published preclinical research and does not constitute medical advice or claims.