≥98%HPLC Purity
COAIncluded
USAShipped
PE-22-28 Peptide
Synthetic spadin analog targeting the TREK-1 potassium channel. Researched for antidepressant-like properties and rapid-onset neurological effects in preclinical models.
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Quick Facts
| SKU | PE22-001 |
|---|---|
| Molecular Formula | C₃₅H₅₇N₁₁O₉ |
| Molecular Weight | 779.89 g/mol |
| Purity | ≥98% |
| Physical Form | Lyophilized Powder |
| Storage | Store at -20°C |
What is PE-22-28?
PE-22-28 is a synthetic 7-amino acid peptide analog of Spadin, a natural neuropeptide that inhibits the TREK-1 potassium channel. TREK-1 blockade increases serotonergic neurotransmission, producing rapid antidepressant-like effects in preclinical models within 4 days, compared to 2-3 weeks for classical SSRIs.
Frequently Asked Questions
How does PE-22-28 differ from SSRIs?
PE-22-28 blocks TREK-1 potassium channels rather than inhibiting serotonin reuptake. This mechanism produces antidepressant-like effects in 4 days vs 2-3 weeks for SSRIs in preclinical models, and does not cause the same desensitization patterns.
For laboratory and research use only. Not intended for human or animal consumption. All product information is derived from published preclinical research and does not constitute medical advice or claims.