≥98%HPLC Purity
COAIncluded
USAShipped
Humanin Peptide
Mitochondria-derived peptide (MDP) researched for potent cytoprotective and anti-apoptotic properties. Studied in neurodegeneration, Alzheimer disease models, and cellular stress.
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Quick Facts
| SKU | HUM-001 |
|---|---|
| Molecular Formula | C₁₂₀H₂₀₈N₃₆O₃₃S₂ |
| Molecular Weight | 2687.22 g/mol |
| Purity | ≥98% |
| Physical Form | Lyophilized Powder |
| Storage | Store at -20°C |
What is Humanin?
Humanin is a 24-amino acid mitochondria-derived peptide (MDP) encoded by mitochondrial DNA. It is one of the most potent endogenous cytoprotective factors discovered, protecting cells against apoptosis induced by amyloid-beta, oxidative stress, and serum deprivation. Humanin levels decline with age, correlating with increased vulnerability to neurodegeneration.
Mechanism of Action
Humanin exerts cytoprotection through multiple pathways: (1) Binds IGFBP-3, releasing free IGF-1; (2) Activates STAT3 via the CNTFR/WSX-1/gp130 tripartite receptor; (3) Directly interacts with Bax protein, preventing mitochondrial membrane permeabilization and cytochrome c release; (4) Activates AMPK and MAPK/ERK survival pathways.
Frequently Asked Questions
Why does humanin decline with age?
Humanin is encoded by mitochondrial DNA, and mitochondrial function declines with aging. As mitochondrial copy number and transcription decrease, humanin production falls, potentially contributing to increased cellular vulnerability to stress and neurodegeneration.
For laboratory and research use only. Not intended for human or animal consumption. All product information is derived from published preclinical research and does not constitute medical advice or claims.