≥98%HPLC Purity
COAIncluded
USAShipped
FOXO4-DRI Peptide
D-retro-inverso peptide disrupting FOXO4-p53 interaction. Studied for senescent cell biology and cellular senescence pathways.
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| SKU | ACR-FOXO4 |
|---|---|
| Molecular Weight | 4827.00 g/mol |
| Sequence | D-retro-inverso modified peptide |
| Purity | ≥95% |
| Physical Form | Lyophilized Powder |
| Storage | Store at -20°C |
What is FOXO4-DRI?
FOXO4-DRI is a D-retro-inverso (DRI) peptide designed to disrupt the FOXO4-p53 protein-protein interaction within senescent cells. The DRI modification uses D-amino acids assembled in reverse order, creating a peptide with protease resistance while maintaining the topological presentation of side chains necessary for target binding.
Senescent cells accumulate with age and secrete a pro-inflammatory cocktail known as the senescence-associated secretory phenotype (SASP). The FOXO4-p53 complex normally protects senescent cells from apoptosis. FOXO4-DRI was designed to competitively disrupt this protective interaction.
For laboratory research use only.
Frequently Asked Questions
What is FOXO4-DRI?
FOXO4-DRI is a D-retro-inverso peptide that disrupts the FOXO4-p53 complex in senescent cells. D-amino acids provide protease resistance. By breaking the protective FOXO4-p53 interaction, it may selectively target senescent cells. For research use only.
For laboratory and research use only. Not intended for human or animal consumption. All product information is derived from published preclinical research and does not constitute medical advice or claims.