≥98%HPLC Purity
COAIncluded
USAShipped
DSIP Peptide
Delta Sleep-Inducing Peptide. A nonapeptide originally isolated from cerebral venous blood, studied in neuroscience research.
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| SKU | ACR-DSIP |
|---|---|
| CAS Number | 62568-57-4 |
| Molecular Formula | C35H48N10O15 |
| Molecular Weight | 848.81 g/mol |
| Sequence | Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu |
| Purity | ≥99% |
| Physical Form | Lyophilized Powder |
| Storage | Store at -20°C |
What is DSIP?
DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, WAGGDASGE) with MW 848.81 g/mol and CAS 62568-57-4. First isolated in 1974 from the cerebral venous blood of rabbits during induced sleep (Schoenenberger-Monnier group, Basel), DSIP promotes delta wave (Stage 3/4) sleep — the deepest, most restorative phase of the sleep cycle.
DSIP crosses the blood-brain barrier and acts on multiple neuroendocrine systems: it modulates GABA and glutamate signaling, suppresses cortisol and ACTH, enhances LH release, and regulates somatostatin/GH secretion patterns. Its research profile spans sleep medicine, stress physiology, circadian biology, and endocrine regulation.
Mechanism of Action
Delta Wave Enhancement: DSIP promotes EEG delta wave activity (0.5-4 Hz), increasing the duration and depth of Stage 3/4 slow-wave sleep without suppressing REM sleep. The mechanism involves modulation of GABAergic interneurons in the ventrolateral preoptic area (VLPO).
Cortisol/ACTH Suppression: DSIP reduces ACTH and cortisol secretion, potentially explaining stress-buffering effects. It normalizes the HPA axis response in chronic stress models.
Somatotropin Modulation: DSIP enhances the nocturnal GH pulse amplitude during delta sleep, connecting sleep architecture to growth hormone research.
Research & Clinical Studies
Research: Stress and HPA Axis
DSIP demonstrates anxiolytic and stress-buffering properties independent of its sleep-promoting effects. Research shows DSIP normalizes the hypothalamic-pituitary-adrenal (HPA) axis response to chronic stress, reducing basal and stress-induced cortisol/corticosterone levels. In animal models of chronic mild stress, DSIP restored normal HPA axis reactivity and reversed anhedonia-like behavior.
Research: Pain Modulation
DSIP has been investigated as an analgesic in chronic pain research. Studies report: potentiation of endogenous opioid analgesia (enhanced enkephalin activity), reduced pain perception in chronic headache patients (open-label trial), and modulation of nociceptive thresholds without opioid receptor dependence. The mechanism may involve delta-opioid receptor sensitization and serotonergic pain modulation.
DSIP and Opioid/Alcohol Withdrawal Research
One of the most promising DSIP research directions is substance withdrawal management. Clinical studies (Dick et al., 1984; Schneider-Helmert, 1985) reported DSIP administration during alcohol and opioid withdrawal: normalized sleep architecture disrupted by withdrawal, reduced anxiety and psychomotor agitation, decreased withdrawal symptom severity scores, and restored normal cortisol circadian patterns. The mechanism involves normalization of GABA/glutamate balance and HPA axis function — the two systems most disrupted during withdrawal states.
[1] Dick P et al. DSIP in the treatment of withdrawal syndromes from alcohol and opiates. Eur Neurol. 1984;23(5):356-363. PubMed ↗
DSIP and Endocrine Modulation
DSIP demonstrates broad endocrine modulatory effects: suppresses ACTH and cortisol (anti-stress), enhances LH release (reproductive axis), modulates somatostatin/GH patterns (increases nocturnal GH pulse), and normalizes TSH circadian rhythm. This multi-axis endocrine modulation is unusual for a single nonapeptide and suggests DSIP acts at a high level of neuroendocrine integration, possibly at the level of the suprachiasmatic nucleus (SCN) circadian pacemaker.
DSIP and Immune Function
Immunological research shows DSIP enhances NK cell activity, increases lymphocyte proliferation in response to mitogens, and modulates cytokine production (TNF-α suppression, IL-10 enhancement). The immunomodulatory effects are linked to its sleep-promoting activity — deep sleep (Stage 3/4) is when immune surveillance peaks, growth hormone is secreted, and tissue repair occurs. By enhancing delta sleep, DSIP indirectly supports immune function through the neuroimmune sleep-immunity axis.
Chemical Properties
| Sequence | Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (WAGGDASGE) |
|---|---|
| Formula | C₃₅H₄₈N₁₀O₁₅ |
| MW | 848.81 g/mol |
| CAS | 62568-57-4 |
| Amino Acids | 9 (nonapeptide) |
| Origin | Endogenous, isolated from rabbit cerebral venous blood (1974) |
| Purity | ≥98% HPLC |
Handling & Reconstitution
Reconstitute with bacteriostatic water. DSIP dissolves readily as a hydrophilic nonapeptide. For 5mg vial: 1 mL BAC water = 5 mg/mL. Protect from light after reconstitution — tryptophan residue (position 1) is UV-sensitive and can undergo photo-oxidation.
Storage & Stability
Lyophilized: -20°C for 24 months. Reconstituted: 2-8°C, use within 14 days. DSIP contains tryptophan (photosensitive) — protect from light.
Frequently Asked Questions
What type of sleep does DSIP promote?
DSIP specifically promotes delta wave (Stage 3/4) slow-wave sleep — the deepest phase where tissue repair, immune function, and GH secretion peak. Importantly, it does not suppress REM sleep like benzodiazepines do.
How was DSIP discovered?
DSIP was isolated in 1974 by Schoenenberger and Monnier in Basel, Switzerland. They collected cerebral venous blood from rabbits during electrically induced sleep and purified the fraction that could induce delta sleep when administered to recipient animals.
Does DSIP affect growth hormone?
Yes, DSIP enhances the nocturnal GH pulse amplitude during delta sleep. Since 70% of daily GH secretion occurs during slow-wave sleep, DSIP research connects sleep architecture to the somatotropic axis.
Does DSIP have addictive potential?
No evidence of DSIP dependence or tolerance has been reported in research. Unlike benzodiazepines or Z-drugs, DSIP does not act through GABA-A receptor direct agonism and does not produce the reward circuit activation associated with addictive substances.
Is DSIP found naturally in humans?
Yes, DSIP is an endogenous nonapeptide found in human blood, CSF, and brain tissue. It is synthesized primarily in the hypothalamus and released into circulation. Levels fluctuate with circadian rhythm, peaking during the early sleep period. Exogenous DSIP supplementation augments the natural sleep-promoting signal.
How does DSIP compare to melatonin for sleep research?
Different mechanisms: melatonin signals darkness onset (circadian timing), while DSIP directly promotes delta wave sleep architecture (sleep depth). Melatonin helps with sleep onset; DSIP enhances sleep quality. They target complementary aspects of sleep physiology and are sometimes studied in combination.
What is delta wave sleep and why does it matter?
Delta sleep (Stage 3/4, slow-wave sleep) is the deepest sleep phase characterized by 0.5-4 Hz EEG waves. During delta sleep: 70% of daily growth hormone is secreted, immune surveillance peaks, tissue repair occurs, and memory consolidation (declarative) takes place. Decline in delta sleep is one of the earliest biomarkers of aging.
For laboratory and research use only. Not intended for human or animal consumption. All product information is derived from published preclinical research and does not constitute medical advice or claims.