AOD-9604 Peptide

AOD-9604 (Anti-Obesity Drug 9604) is a synthetic peptide fragment corresponding to amino acids 176-191 of human growth hormone (hGH), with an additional tyrosine residue at the N-terminus. This 16-amino acid peptide was designed to isolate the lipolytic activity attributed to the C-terminal region of hGH. Published research has investigated AOD-9604 as a modified fragment that retains specific metabolic signaling properties without the growth-promoting effects associated with full-length growth hormone. The peptide has been studied for its interaction with beta-3 adrenergic receptors and downstream lipolytic signaling. For laboratory research use only.

Beta-3 Adrenergic Receptor Interaction Published research suggests AOD-9604 may interact with beta-3 adrenergic receptors expressed in adipose tissue. These receptors, when activated, stimulate adenylyl cyclase, increase cAMP levels, and activate protein kinase A (PKA), which phosphorylates hormone-sensitive lipase (HSL). Distinction from Full-length hGH Unlike complete growth hormone, AOD-9604 research indicates it does not activate the GH receptor or JAK2-STAT5 signaling pathway. Published studies have documented that AOD-9604 does not affect IGF-1 levels or produce diabetogenic effects observed with chronic GH exposure, suggesting a distinct mechanism limited to the C-terminal fragment activity.