Research Articles

In-depth guides, research summaries, and educational content for the scientific community.

Survodutide vs Tirzepatide: Two Ways to Build a Dual Agonist

Survodutide vs Tirzepatide: Two Ways to Build a Dual Agonist

Both survodutide and tirzepatide are dual agonists — but they target entirely different receptor pairs. This mechanistic comparison breaks down what each architectural choice means for energy expenditure, gastric emptying, and hepatic signaling in research models.

Aug 10, 2026 · 12 min read
["incretin agonists" "GLP-1 receptor" "glucagon receptor"
Survodutide (BI 456906): GLP-1/Glucagon Dual Agonist Research Overview

Survodutide (BI 456906): GLP-1/Glucagon Dual Agonist Research Overview

Survodutide (BI 456906) is a dual GLP-1/glucagon receptor co-agonist currently in Phase 3 trials, offering researchers a mechanistic control compound that isolates glucagon receptor contributions to energy expenditure and hepatic lipid metabolism — without the GIP axis present in tirzepatide or retatrutide.

Aug 10, 2026 · 13 min read
["Incretin Agonists" "GLP-1 Research" "Glucagon Receptor"
Retatrutide Cost: What Determines Research-Supply Pricing

Retatrutide Cost: What Determines Research-Supply Pricing

Retatrutide has no retail price because it has no regulatory approval — any figure circulating online is speculation. This article examines what actually drives research-supply costs for a 39-residue fatty-acid-conjugated peptide, from synthesis difficulty to purity certification.

Aug 10, 2026 · 12 min read
["Retatrutide" "Peptide Pricing" "Research Peptides"
How to Reconstitute Research Peptides With Bacteriostatic Water

How to Reconstitute Research Peptides With Bacteriostatic Water

A complete arithmetic guide to reconstituting lyophilized research peptides with bacteriostatic water — covering concentration formulas, syringe unit conversion, a dosing table for 5 mg through 60 mg vials, and troubleshooting for cloudy or gel-like solutions.

Aug 10, 2026 · 12 min read
["bacteriostatic water" "peptide reconstitution" "research peptides"
Where to Buy Bacteriostatic Water: Pharmacy, Retail and Research Supply

Where to Buy Bacteriostatic Water: Pharmacy, Retail and Research Supply

Bacteriostatic water for injection carries prescription-item status in the United States — a regulatory fact that shapes every purchasing channel differently. This guide maps what actually happens at chain pharmacies, online marketplaces, and laboratory research suppliers, so researchers can make an informed sourcing decision.

Aug 10, 2026 · 12 min read
["bacteriostatic water" "research supply" "peptide reconstitution"
Bacteriostatic Water Storage, Shelf Life and the 28-Day Rule

Bacteriostatic Water Storage, Shelf Life and the 28-Day Rule

The 28-day window after first puncture is not arbitrary — it is a direct consequence of what 0.9% benzyl alcohol actually does at the molecular level. This guide separates the three distinct stability states of bacteriostatic water and explains exactly why each one follows different rules.

Aug 10, 2026 · 11 min read
["bacteriostatic-water" "storage" "reconstitution"
Tesamorelin Reconstitution and Handling in the Laboratory

Tesamorelin Reconstitution and Handling in the Laboratory

A complete laboratory guide to reconstituting tesamorelin lyophilisate across 5 mg, 10 mg, and 20 mg vials — covering solubility chemistry, cloudiness troubleshooting, and stability data for lyophilised versus reconstituted material.

Aug 10, 2026 · 13 min read
["Tesamorelin" "Peptide Reconstitution" "Laboratory Handling"
Tesamorelin Safety Profile and Regulatory Status: What the Trials Recorded

Tesamorelin Safety Profile and Regulatory Status: What the Trials Recorded

A systematic review of what Phase 3 clinical trials actually measured about tesamorelin's safety — organized by organ system, attributed to specific studies, and framed without conjecture. Includes a direct answer to the FDA approval question and a factual account of the GH/IGF-1 and cancer biology question.

Aug 10, 2026 · 13 min read
["Tesamorelin" "GHRH analogs" "Regulatory status"
Tesamorelin vs Sermorelin: GHRH Analogs Compared in the Research Record

Tesamorelin vs Sermorelin: GHRH Analogs Compared in the Research Record

Tesamorelin and sermorelin are both synthetic GHRH analogs acting on the same pituitary receptor, yet they differ fundamentally in molecular stability, plasma half-life, and the volume of clinical evidence behind them. This analysis maps those differences across the published research record.

Aug 10, 2026 · 14 min read
["tesamorelin" "sermorelin" "GHRH analogs"
Comparison of GLP-1 receptor agonist peptides semaglutide tirzepatide and retatrutide

Retatrutide vs Tirzepatide: Triple Agonist Compared to Dual Agonist

A detailed comparison of three incretin-based research peptides — mono-agonist semaglutide, dual-agonist tirzepatide, and triple-agonist retatrutide — covering receptor pharmacology, structural modifications, binding kinetics, metabolic pathway engagement, and practical considerations for laboratory research.

Aug 10, 2026 · 14 min read
GLP-1 Metabolic Research Semaglutide
Retatrutide Dosage in Clinical Trials: Regimens Reported in the Literature

Retatrutide Dosage in Clinical Trials: Regimens Reported in the Literature

A review of the dose escalation regimens, maintenance arms, and titration rationale documented in published phase 1 and phase 2 clinical trials of retatrutide — an investigational triple incretin receptor agonist with no regulatory approval in any jurisdiction.

Aug 10, 2026 · 12 min read
["Retatrutide" "Clinical Trials" "Dose Escalation"